The leadership of the team demonstrated by Dr. Fuks and his management of the different projects are prooving successful, as exemplified by the publication of his work as senior author in high-quality journals such as EMBO J. or Nature. Regarding the CANCERDIP project, François Fuks discovered a novel connection between two key epigenetic systems:

DNA methylation and the Polycomb proteins (Viré et al., Nature 2006). In that respect, the lab of Dr. Fuks has acquired technical expertise and has developped several assays and tools regarding the link between DNA methylation and Polycomb. For exemple, this lab found novel DNMT- and PcG-target genes, developed DNA methyltransferase assays and stably introduced into cells by retroviral transduction vectors siRNAs directed against every DNA methylation component as well as against PcG proteins. Dr. Fuks benefits from very good infrastructures to work on epigenetic at the Free University of Brussels and has all the facilities needed to perform the outlined work.